"The Skelton System has ability to regenerate itself as a part of repair process.
An individual body consist of 206 individual bones"


"Providing that matters in Bone Grafting"

HomeProducts ╗ Bone Graft Substitute


Truly Synthetic Biocompatible Bone Graft Substitute.

B-OstIN is synthetic bone graft substitute, which is prepared by wet chemical processing. The best chemical available are used in manufacturing of phase pure synthetic B-OstIN (HAP). The manufacturing process conforms to ASTM standards.

means Basic OsteoINtegration and is providing that matters in bone grafting.

What matters most in bone grafting?
The most important features that a bone graft substitute must possess to offer successful bone integration with the host bone are as mentioned below.
  • Biocompatible - It first and the foremost requirement for any device to be implemented, because of increased awareness of safety.
  • Osteoconductive - For faster bone integration between host bone and bone graft substitute.
  • Non-Immunogenic - The implement should not be a vector of disease transmission or it should not give any adverse effects after its implementation.
B-OstIN addresses these features:
  • Biocompatible - B-OstIN has been implemented over 500 patients with minimum 12 months of follow ľup and no adverse effects reported.
  • Osteoconductive - The most osteoconductive material which helps in bone bonding with in three months , fastest of all ceramics constituents.
  • Non-Immunogenic - No cytotoxicity or adverse effects have been reported after the implementation of B-OstIN.

Biocompatibility (Read more)

The biocompatibility of a long-term implementable medical implement refers to the ability of the device to perform its intended function, with the desired degree of incorporation in the host, without eliciting any undesirable local or systemic effects in that host.

The increase in awareness of the safety of medical devices has taken an international character, in large part because of the convergence of FDA regulations and International Organization for Standardization (ISO) standards. As international requirements for the biological evaluation of materials continue to be developed and issued, the use of the chemical characterization of materials to establish biocompatibility has become essential.
Biocompatible B-OstIN - Animal/ Clinical Studies
  • Animal Studies - Rabbit Tibia
    Histological sections showing progressive bone formation in rabbit tibia around
    B-OstIN granule at various time periods.


  • Clinical Study - Tibia Plateau fracture study

                            The Fracture                                      Immediate Post Operative

                       Follow up 6 months                      Follow up 1year Granule are
    still visible
                     (well healed fracture)                       but bone granule
    boundary is distinct

Osteoconductivity (Read more)

The ability of a implement to act as scaffolding that supports new bone formation and the bone growth.
Factors that influence osteoconductive nature of a bone graft are its chemical composition and morphology.

Chemical Composition
The Ca/p ratio present in hydorxyapatite of natural bone is 1.67 . Any ceramic material having Ca/ P nearer to or similar 1.67 will be good osteoconductive.

Porosity and interconnectivity among macro and micro pores also influence the osteoconductive feature of a bone graft substitute. Bone is living tissue that grows into implement incorporating it into the body. More porous the implement more space is available for bone to grow in and secure the implement.But , Porosity also influences the mechanical strength of the implement . Highly porous the material , lesser the mechanical strength .Therefore we need to have an implement with optimum porosity, that allows good mechanical strength.

Osteoconductive B-OstIN- Chemical Composition and porosity

  • Chemical Composition - Chemically phase pure Hydroxyapatite prepared by wet chemical processing. The strict control on the process ensures Phase Purity and crystallinity as depicted by X-Ray Diffraction Analysis.

                                               X-Ray Diffraction with Single Peak                                    
  • Morphology - Te Ca/ P ratio is 1.67 in B-OstIN is exactly similar to mineral content of human bone. It makes B-OstiN the most osteoconductive material.
  • Porosity and Pore Size - The porosity of 60 to 70 percent with pore size ranging between 100-300  Ám is the most optimum for bone in growth.

                                      Porosity Distribution graph showing tight control                         
  • Purity - The trace elements are maintained within limits defined by ASTM-1185-88.
Non-Immunogenic (Read more)
Any implement to be placed inside the human body, it should not be vector of disease transmission. Moreover its implementation shall not depend on suppression of immune system of the recipient . Suppression of immune system will make the recipient body susceptible to various infections. Therefore, non-immunogenic feature of an implement influences its usage.

A product is said to be non-immunogenic, if body does not produces an anti-body response against the implemented material. Once the metal implement has been incorporated in the host environment it should not give any systemic or local adverse effect.

To establish the Non- Immunogenic nature of the in-vitro and in-vivo tests should be performed. These test includes cytotoxicity, subcutaneous implementation and hemolysis test. The results of these in-vitro and in- vivo studies should be documented and published.

Non-Immunogenic - Test as per ISO 10993 (Biological Evaluation of Medical Devices)
  • Haemolysis test - B-OstIN does not result in lysis of Red Blood Cells.
    The Haemolysis of the finished products is less than 2% where as the ISO 10993 Standard defines maximum limit as 5%.

    Intact RBC over
    B-OstIN after Haemolysis test
  • Cytotoxicty test - B-OstIN does not show any cytotoxic effects in contact with L 929 Cell Culture.

    No Cytotoxicty effect on contact with
  • Subctaneous Implementation test - B-OstIN proved to be successful in prolonged test with soft tissues.
    • Implements surrounded by cellular infiltrate which was predominantly fibroblastic.
    • Macrophages , lymphocytes and plasma cells also present at the site.
    • No tissue necrosis and acute inflammation.

Indications for use:
                          Spinal Fusion                                     Vertebral Fracture        Bone Void Filler (Bone TB)


    Tibia Plateau Fracture           Distal Radius Fracture                    Calcaneus Fracture

Product Presentation

B-OstIN Granules

B-OstIN Rod

B-OstIN Block

Basic Health Care © 2007-. All Rights Reserved.

Privacy Policy | Terms of Use

Creation 'n' Care by: VARR Technologies

About Us

  Professionals   Patients   Careers   Contact Us
  Who we are?   Application of Bone Graft   What is Bone?   HR Philosophy   Basic Healthcare Products Pvt. Ltd.
  How we do?   Clinical Relevance   What is Bone Graft?   Benefits   Phone: +91-7087804874
  Management   Why HAP?   Why Synthetic Bone Graft?   Open Positions   Email: distribution2017@b-ostin.com
          Application of Bone Graft?   Showcase admin@b-ostin.com
          Advantages & Disadvantages   Extranet Website: www.b-ostin.com